Fluoroacetate Toxic
A man was found having nausea, vomiting and abdominal pain, sweating, confusion and agitation follow. His next of kin told the triage that he accidentally swallow a rodent poison, which he thought it is some kind of candy placed on the kitchen table. The lab results were positive for fluoroacetate toxic.
As a pathology researcher, you have to explain the whole situation (biochemically) to a bunch of industrial trainees in your pathology lab.
As a pathology researcher, you have to explain the whole situation (biochemically) to a bunch of industrial trainees in your pathology lab.
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Treatment
- If ingested, vomiting should be induced immediately followed by gastric lavage with two to four litres of tap water and instillation of 15-30 g of saline cathartic.
- Monoacetin (glyceryl monoacetate) 0.5 mg/kg should be injected IM every half hour for 12 hours varying the injection sites.
- Artificial respiration with the assistance of oxygen may be required.
- Calcium gluconate, 2-3 g per day in 10% solution may be given IV.
- To control convulsions barbiturates (preferably phenobarbitone or pentobarbitone) should be given IM or IV in sufficient dosage