Lactic Acidosis
Lactic acidosis is a physiological condition characterized by low pH in body tissues and blood (acidosis) accompanied by the buildup of lactate, especially L-lactate, and is considered a distinct form of metabolic acidosis. Lactic acidosis is characterized by lactate levels >5 mmol/L and serum pH <7.35.
In a Young Biochemist Association Forum, you are invited to explain about the condition and how DCA could treat it.
In a Young Biochemist Association Forum, you are invited to explain about the condition and how DCA could treat it.
Problem Solving
Pyruvate Dehydrogenase Complex (PDC) is regulated by reversible phosphorylation. A phosphorylated PDC will be in inactive form. If PDC kinase catalyze the phosphorylation of PDG, it will inhibit pyruvate oxidation. If glycolysis occur without pyruvate oxidation, lactate will accumulate. Each of molecule of lactate produced will be accompanied with hydrogen ion. DCA can treat LA by being a potent inhibitor of PDC kinase. DCA increases PDC activity by inhibiting the activity of PDC kinase in all tissues. When PDC kinase is inhibited, PDH, will be in its unphosphorylated (active) form. Active form of PDH will start the oxidation of Pyr to Acetyl CoA.
Slides
Refer the link below for more information:
https://drive.google.com/file/d/0B5-mV92PEbG2VWtub184S2hrMUk/view?usp=sharing
https://drive.google.com/file/d/0B5-mV92PEbG2VWtub184S2hrMUk/view?usp=sharing